There were a lot of accomplishments from March to May in the Department of Pharmaceutical Sciences! The notable list includes:

Christine dengler-Crish, Ph.D.

grants

• 1R56AG069116-01A1 NATIONAL INSTITUTE ON AGING 2021. Mechanism of ZCCHC6 Regulation of Mitochondrial Dysfunction In Alzheimer’s Disease. PI: T. Haqqi, Co-I: C. Dengler-Crish, M. Ansari, S. Fleming, Z. Zhu.
  Award: $751,425

peer-reviewed publications

• Katie A Bretland, Li Lin, Kimberly M Bretland, Matthew A Smith, Sheila M Fleming, Christine M Dengler-Crish. 2021. Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. Neuropathol Appl Neurobiol, Mar 26. doi: 10.1111/nan.12711.

altaf darvesh, Ph.D.

awards

• Selected by COP Class of 2021 as a Commencement Hooder

Sheila Fleming, Ph.D.

grants

• 1R56AG069116-01A1 NATIONAL INSTITUTE ON AGING 2021. Mechanism of ZCCHC6 Regulation of Mitochondrial Dysfunction In Alzheimer’s Disease. PI: T. Haqqi, Co-I: C. Dengler-Crish, M. Ansari, S. Fleming, Z. Zhu.
  Award: $751,425

peer-reviewed publications

• Annand CT, Fleming SM, Holden JG (2021). Farey trees explain sequential effects in choice response time. Frontiers in Physiology, in press.
• Katie A Bretland, Li Lin, Kimberly M Bretland, Matthew A Smith, Sheila M Fleming, Christine M Dengler-Crish. 2021. Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. Neuropathol Appl Neurobiol, Mar 26. doi: 10.1111/nan.12711.

abstracts/posters/presentations

• Guest Speaker- Seminar Series, Department of Neurobiology & Behavior, SUNY Stony Brook, NY”ATP13A2: Environmental and genetic interactions in Parkinson’s disease”. (April 1, 2021)

awards

• Awarded 2021 College of Pharmacy Excellence in Scholarship Award

takhar kasumov, Ph.D.

grants

• NIH/NIDDK (PI: Schelling W., Metro Health) 05/01-2021-03/31/2026
  Role: Co-Investigator
  Title: Mechanisms of Tubular Atrophy in Renal Disease
• North East Ohio Alcohol Center Pilot Grant 06/01/2021-04/31/2022
  Role: Principal Investigator
  Title: Temporal changes in hepatic proteome and acetylome in response to alcohol.
  Award: $20,000/yr
• I-CORPS@OH 05/01/2021-11/30/2021
  Role: Principal Investigator
  Title: Apomarker – Serum levels of glycated ApoAI, a novel biomarker to screen for pre-diabetes and diabetes and their cardiovascular complications
  Award: $12,500

peer-reviewed publications

• Arias-Alvarado A., Aghayev M., Ilchenko S., Rachdaui N., Lepp J., Tsai TH, Zhang G., Previs S., Kasumov T*. Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet. Analytical Biochemistry, 2021, 15, 615: 114067.
• Gabisonia K., Burjanadze G., Woitek F., Keles A., Seki M., Gorgodze N., Carlucci L., Ilchenko S., Kurishima C., Walsh K., Piontkivska H., Recchia F. A., Kasumov T*. Dynamic proteomics and bioinformatics reveal major alterations in the turnover rate of functionally related cardiac and plasma proteins in a dog model of congestive heart failure. Journal of Molecular Cellular Cardiology, 2021 (in review).

abstracts/posters/presentations

• Arias-Alvarado A., Ilchenko S., E.Reed, Kashyap, S., Kasumov T. Glycation of the lipoprotein ApoAI is a novel biomarker for early predicting diabetic cardiovascular complications. TechConnect, October 18-21, 2021, Washington DC (submitted).

moses oyewumi, Ph.D.

abstracts/posters/presentations

• “Assessment of 3D-Printed Scaffolds as a Platform for Bone Delivery of Gallium Acetyl Acetonate” will be presented at the 2021 Annual meeting of American Association of Pharmaceutical Scientists.

erin reed-geaghan, Ph.D.

grants

• Awarded $100,000/year for 3 years from BrightFocus Foundation to support the project “Developmental determinants of sexually divergent neuroinflammatory processes in Alzheimer’s disease”.

peer-reviewed publications

• Casali BT, Reed-Geaghan EG. (2021) Microglial function and regulation during development, homeostasis and Alzheimer’s disease. Cells: in press.

abstracts/posters/presentations

• The abstract “Sex specific dependence on nuclear receptor-mediated myeloid cell activation in Alzheimer’s disease” was accepted for a poster presentation at the 2021 annual Organization for the Study of Sex Differences meeting.

awards

• Awarded 2021 College of Pharmacy Innovation in Teaching Award

austin shin, Ph.D.

awards

• Awarded 2021 P1 Teacher of the Year Award

matthew smith, Ph.D.

peer-reviewed publications

• Katie A Bretland, Li Lin, Kimberly M Bretland, Matthew A Smith, Sheila M Fleming, Christine M Dengler-Crish. 2021. Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. Neuropathol Appl Neurobiol, Mar 26. doi: 10.1111/nan.12711.

xinwen wang, Ph.D.

peer-reviewed publications

• Wang X, Her L, Xiao J, Shi J, Wu A. H., Bleske B. E., and Zhu HJ, Carboxylesterase 1 genetic polymorphism on trandolapril activation in human and the pharmacokinetics and pharmacodynamics in healthy volunteers, Clin Transl Sci, 2021
• Li J, Liu S, Shi J, Wang X, Xue Y, and Zhu HJ, Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy, ACS Pharmacol. Transl. Ssi. 2021, 4 (2): 870-887